I had a phenomenal stay at Tophane Suites! The rooms were extremely clean and modern. I had a rental car that they parked for me in their private garage; the street was quite busy and when I arrived to check in there was no street parking left, so I just put my hazards on and someone came out right away to move my car (and I think that's the norm). While I was there, I was trying to plan the rest of my trip (all very last minute), and the front desk was SO helpful, calling people for me, looking up airline promo codes for me (I ended up with 10% off my flight to Cappadocia), and just above and beyond what I'd expect of any hotel front desk. As for the location, it's in a neighbourhood of narrower streets and alleys, so it's quieter at night. BUT it was still close enough to be within walking distance of the lively restaurant/pub areas and the major tourist attractions (Hagia Sophia, Grand Bazaar, etc). The hotel told me about lots of transport options, but I liked the ~40min walks. Overall I would highly recommend staying here if you want a mix of modern/lively and cultural/historical Istanbul.