Cheap Flight Deals to Santa Cruz S from CA $334

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

How to find cheap flights to Santa Cruz?

The cheapest prices found with in the last 7 days for return flights were CA $386 and CA $334 for one-way flights to Santa Cruz for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel datesFlights from*
SCLSanta CruzMarch 14 to March 25CA $584
MIASanta CruzMarch 22 to March 29CA $747
MEXSanta CruzApril 22 to May 7CA $820
IADSanta CruzMarch 15 to March 25CA $825
IADSanta CruzMarch 15 to March 25CA $825
PTYSanta CruzMarch 12 to March 22CA $939
LAXSanta CruzMarch 15 to March 25CA $1,072
MADSanta CruzMarch 19 to March 25CA $1,147
IAHSanta CruzMay 31 to June 18CA $1,179
FCOSanta CruzMarch 18 to March 25CA $1,353
*Prices include taxes and fees
OriginDestinationTravel datesFlights from*
PTYSanta CruzMarch 9 to March 16CA $1,146
MADSanta CruzMarch 9 to March 20CA $1,633
*Prices include taxes and fees

Your guide to flights to Santa Cruz, S

GOL Linhas Aereas S.A., Paranair, Delta, Copa fly to Santa Cruz, so use Travelocity to search, find, and compare some truly tempting deals from the 4 airlines—that way you can be sure you’ve found the best deal for you. A flight to Santa Cruz S currently costs between CA $386 and CA $1,633. Prices vary, but for the best fares, travel in June when prices are at their lowest.  

Top tips for finding cheap flights to Santa Cruz  

The cheapest flight for a round trip to Santa Cruz is currently CA $386. When you search for flights to Santa Cruz, enter your preferred travel dates then click on ‘flexible dates’ to compare cheap flight tickets to Santa Cruz for nearby days.  The cheapest month to travel to Santa Cruz is March from our list of deals available.  

But if you’re flexible about when you travel, you can find great deals on flights across the year. If you’re planning a vacation, you can save more on Travelocity when you bundle flights with car rental and hotel bookings, too. Many airlines currently offer flexible booking options, so look for flights offering no change fees.   

How to cancel flights to Santa Cruz 

We know plans change, that’s why at Travelocity, we make it as easy as possible for you to cancel or amend your plane tickets. Go to My Trips, enter your itinerary number, then follow the instructions. Many airlines let you cancel flights online free of charge if you booked it in the last 24 hours. Visit Customer Service for more advice.  

Why you should book your flight to Santa Cruz with Travelocity 

We have top deals on plane tickets even for last minute flights to Santa Cruz, so you can simply type in your travel dates and compare our best prices. Booking with Travelocity means you get flexible cancellation options, 24/7 support, and, thanks to our Price Match Promise, if the airfare drops after you book, you can get a refund! Whether you’re planning a business trip, weekend getaway, or a family vacation—let Travelocity get you to Santa Cruz for less. 

Find The Perfect Hotel For After Your Flight

Amazing Place to Stay After Flight to Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
The price is CA $183 per night from Mar. 25 to Mar. 26
CA $183
CA $183 total
includes taxes & fees
25 Mar - 26 Mar
Stay at this 3.5-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (309 reviews)
"Very good quality hotel in beautiful Santa Cruz, Bolivia. Friendly staff Clean grounds"

Reviewed on 15 Jan. 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 out of 5
Dr Victor Pinto, Equipetrol, esquina Marcelo Terceros Banzer, Santa Cruz
The price is CA $93 per night from Mar. 6 to Mar. 7
CA $93
CA $100 total
includes taxes & fees
6 Mar - 7 Mar
Stay at this 3.5-star hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are ...
8/10 Very Good! (198 reviews)
"So, the mattress and pillows were not that comfortable, hard. No microwave and the sheets not the size of the bed, smaller. The treatment from the hotel personnel was good."

Reviewed on 21 Feb. 2025

Hotel LP Equipetrol
Yotau All Suites Hotel

Yotau All Suites Hotel

3.5 out of 5
Av. San Martin No. 7, Santa Cruz
The price is CA $180 per night from Mar. 6 to Mar. 7
CA $180
CA $180 total
includes taxes & fees
6 Mar - 7 Mar
Stay at this 3.5-star family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...
6.8/10 (75 reviews)
"I like everything"

Reviewed on 19 Apr. 2023

Yotau All Suites Hotel
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Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

3 out of 5
Av.Ejercito Nacional 290, (frente Stadium Tahuichi), Santa Cruz
The price is CA $72 per night from Mar. 8 to Mar. 9
CA $72
CA $79 total
includes taxes & fees
8 Mar - 9 Mar
Stay at this 3-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...
7.8/10 Good! (277 reviews)
"Clean, friendly staff"

Reviewed on 2 Jun. 2024

Hotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz hotel with Airport Shuttles

Casa Vida

Casa Vida

3.5 out of 5
Condominio Club Campestre, Kilometro 13 doble via La Guardia, Santa Cruz, Santa
Stay at this 3.5-star family-friendly vacation home in Santa Cruz. Enjoy free WiFi, free parking, and private spa tubs.
9/10 Wonderful! (2 reviews)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"

Reviewed on 28 Sep. 2017

Casa Vida
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13, Aeropuerto Internacional Viru Viru, Santa Cruz, Santa Cruz
The price is CA $156 per night from Mar. 6 to Mar. 7
CA $156
CA $156 total
includes taxes & fees
6 Mar - 7 Mar
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (282 reviews)
"Super easy check in, most of the details are handled by Expedia. It’s a great place to relax before an early morning flight out of VVI. Clean, comfortable and everything you need."

Reviewed on 1 Mar. 2025

Sun Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
The price is CA $183 per night from Mar. 25 to Mar. 26
CA $183
CA $183 total
includes taxes & fees
25 Mar - 26 Mar
Stay at this 3.5-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (309 reviews)
"Very good quality hotel in beautiful Santa Cruz, Bolivia. Friendly staff Clean grounds"

Reviewed on 15 Jan. 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
The price is CA $183 per night from Mar. 25 to Mar. 26
CA $183
CA $183 total
includes taxes & fees
25 Mar - 26 Mar
Stay at this 3.5-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (309 reviews)
"Very good quality hotel in beautiful Santa Cruz, Bolivia. Friendly staff Clean grounds"

Reviewed on 15 Jan. 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45, a 1 cuadra de la Av. San Martin, Santa Cruz
The price is CA $43 per night from Mar. 17 to Mar. 18
CA $43
CA $43 total
includes taxes & fees
17 Mar - 18 Mar
Stay at this 3.5-star business-friendly aparthotel in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle ...
8.6/10 Excellent! (84 reviews)
"Good location, spacious apartment, good stay overall"

Reviewed on 12 Oct. 2020

Apart Hotel Premium Suites Santa Cruz
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901, Santa Cruz
The price is CA $87 per night from Mar. 6 to Mar. 7
CA $87
CA $87 total
includes taxes & fees
6 Mar - 7 Mar
Stay at this 4-star family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
7.4/10 Good! (90 reviews)
"Extremely satisfy with the service that this resort provided to us. Definitely will return back. Follow me on YouTube #TeamWithERVING"

Reviewed on 14 Aug. 2021

Buganvillas Hotel Suites & Spa
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Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
The price is CA $168 per night from Mar. 11 to Mar. 12
CA $168
CA $168 total
includes taxes & fees
11 Mar - 12 Mar
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Santa Cruz ...
8.8/10 Excellent! (372 reviews)
"Beautiful property!! Staff, location and food outstanding. I go back every time I’m in Bolivia."

Reviewed on 15 Feb. 2025

Camino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a car after flight to Santa Cruz?

Frequently asked questions

Which airlines fly to Santa Cruz?
10 carriers fly to Santa Cruz, which means you won’t be short on choice. Experienced travelers often recommend:

  • BoA
  • Amaszonas
  • Copa Airlines

What airport is best to fly into Santa Cruz?
There’s no need to research flight options into different airports when traveling to Santa Cruz. VVI is the city’s only airport, and is located 16 kilometers from the downtown area.
Where to stay in Santa Cruz
Choosing the perfect place to stay is a key ingredient for an unforgettable travel experience. Select from 174 properties in Santa Cruz and start planning the adventure of your dreams!There’s no more suitable time to truly spoil yourself than when you’re taking a vacation. Lock in a room at the Los Tajibos Hotel And Convention Center and enjoy a taste of the high life during your stay. Traveling with a smaller budget? Don’t worry, you won’t be left out in the cold. The Casa Internacional Los Aventureros will keep you and your hip-pocket happy.
Places to visit in Santa Cruz
0 Need some more options? 0 But that’s not all there is. 0
How to get through airport security fast when traveling to Santa Cruz
If you like the idea of spending more time at the airport restaurants and less time wading through security on your way to Santa Cruz, follow these practical tips:

  • Be sure you know the whereabouts of your travel ID and boarding pass. You don’t want to hold up the queue when you’re asked to hand them over.
  • Bear in mind that belts with metal buckles can set off the body scanner’s alarms. If you have one on, you may be instructed to remove it before continuing.
  • Laptops, digital cameras and other electronic devices must be placed in a tub to be X-rayed.
  • Toothpaste, lip balm and other toiletry items in liquid, gel or cream form need to be stored in containers no larger than 3.4 ounces (100 milliliters). They must also fit in a 1-quart (1-liter) clear zip-lock plastic bag.
  • Consider your choice of footwear. Slippers are great because they’re a cinch to step out of when you’re doing the airport security checks. Try wearing some on your next journey!
  • Some places have stringent biosecurity laws. Consider where you’re off to and whether or not it’s permissible to fly with fresh fruit.

Plane Tickets To Santa Cruz

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Santa Cruz. Browse through our inventory to explore a wide range of cheap flights to Santa Cruz to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Santa Cruz as you anxiously await to exit the plane and explore what Santa Cruz has to offer. Considering all the amazing local food and culture in Santa Cruz, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Santa Cruz to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Santa Cruz without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Santa Cruz with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Santa Cruz today!

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.