
Exclusive Mayo Clinic Florida Vacation Deals
Mayo Clinic Florida vacation package deals
Price found within the past 48 hours. Click for updated prices.

Holiday Inn Express & Suites Orange City - Deltona by IHG
per person
May 18 - May 25
found 4 hours ago
Roundtrip flight included
Toronto (YYZ) to Daytona Beach (DAB)
Book a stay at this business-friendly hotel in Orange City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Central Florida Zoo & Botanical Gardens and AMF Deltona Lanes are located nearby.

The Ritz-Carlton, Amelia Island
Save 100% on your flight
per person
May 23 - May 26
found 1 hour ago
Roundtrip non-stop flight included
Toronto (YYZ) to Jacksonville (JAX)
Stay at this 5-star luxury resort in Fernandina Beach. Enjoy a full-service spa, a beach locale, and a golf course. Our guests praise the property condition in our reviews. Popular attractions Omni Amelia Island Resort Golf and Peters Point Beachfront Park are located nearby.

The Villas of Amelia Island
per person
May 23 - May 26
found 1 hour ago
Roundtrip non-stop flight included
Toronto (YYZ) to Jacksonville (JAX)
Stay at this 4-star beach resort in Fernandina Beach. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions Omni Amelia Island Resort Golf and Amelia Island State Park are located nearby.

Vintage Amelia Island Apartments
per person
May 23 - May 26
found 1 hour ago
Roundtrip non-stop flight included
Toronto (YYZ) to Jacksonville (JAX)
Stay at this 3.5-star apartment in Fernandina Beach. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Fernandina Little Theatre and Egan's Creek Greenway Trail are located nearby.

Legacy Vacation Resorts Palm Coast
per person
May 15 - May 19
found 1 day ago
Roundtrip non-stop flight included
Calgary (YYC) to Daytona Beach (DAB)
Stay at this 3-star family-friendly aparthotel in Palm Coast. Enjoy free parking, a fitness center, and a business center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Palm Coast Resort Golf Club and Palm Harbor Golf Club are located nearby.

Hoyt House Amelia Island
Fernandina Beach Historic District
per person
May 23 - May 26
found 1 hour ago
Roundtrip non-stop flight included
Toronto (YYZ) to Jacksonville (JAX)
Stay at this 3.5-star boutique B&B in Fernandina Beach. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Fernandina Little Theatre and Blue Door Artists are located nearby.
Frequently asked questions
Top Mayo Clinic Florida hotel deals

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
14390 Mayo Boulevard, Jacksonville, FL
Free cancellation
Reserve now, pay when you stay
The price is CA $230 per night
CA $230
CA $261 total
includes taxes & fees
Apr 12 - Apr 13
Stay at this 3-star business-friendly hotel in Jacksonville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions St. Johns Town Center and Jacksonville Beach Pier are located nearby.
Pool
Parking included

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
Free cancellation
Reserve now, pay when you stay
The price is CA $250 per night
CA $250
CA $283 total
includes taxes & fees
Apr 11 - Apr 12
Stay at this 3-star business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions St. Johns Town Center and Jacksonville Beach Pier are located nearby.
Pool
Breakfast included

Margaritaville Jacksonville Beach
715 1st St N, Jacksonville Beach, FL
Free cancellation
Reserve now, pay when you stay
The price is CA $319 per night
CA $319
CA $363 total
includes taxes & fees
Apr 6 - Apr 7
Book a stay at this beach hotel in Jacksonville Beach. Enjoy free WiFi, a beach locale, and breakfast (surcharge). Our guests praise the pool and the bar in our reviews. Popular attractions Jacksonville Beach Pier and Northeast Florida Beaches are located nearby.
Pool
Free WiFi
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.