Eastern Panama Vacations 2025 from CA $1,194

Eastern Panama flight + hotel packages

Price found within the past 48 hours. Click for updated prices.

Villa Botero By Casa Mojito B&B

per person

Jul. 11 - Jul. 18

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 3-star golf B&B in Rio Hato. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Playa Blanca and Farallón Beach are located nearby.

Residencia Natural

per person

Jul. 1 - Jul. 8

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 3-star beach aparthotel in Bastimentos. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Playa Larga and Nivida Bat Cave are located nearby.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

per person

Jul. 1 - Jul. 8

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Punta Caracol Acqua Lodge

Punta Caracol

Save 100% on your flight

per person

Jun. 30 - Jul. 7

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 3.5-star beach lodge in Bocas del Toro. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions La Gruta Cave and Institute for Tropical Ecology & Conservation - Bocas del Toro Biological Station are located nearby.

Las Americas Golden Tower Panama

San Francisco

per person

Jul. 1 - Jul. 8

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Top Eastern Panama hotels deals

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

CA $748

CA $823 total

includes taxes & fees

May 24 - May 25

Stay at this 4.5-star luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

CA $319

CA $351 total

includes taxes & fees

Apr 29 - Apr 30

Stay at this 3-star beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Private Over the Water Cabin on San Blas Island

9.542876, -78.899058, Narganá, San Blas

CA $290

CA $319 total

includes taxes & fees

Apr 27 - Apr 28

Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna Nation and Porvenir Museum are located nearby.

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

CA $247

CA $271 total

includes taxes & fees

Apr 27 - Apr 28

Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attraction Museum of the Kuna Nation is located nearby.

Breakfast included

Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón

CA $157

CA $177 total

includes taxes & fees

May 26 - May 27

Stay at this 3-star hotel in Puerto Lindo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Private wood Cabins on San Blas island - private bathroom

Wailidup Island, Narganá, Guna Yala

Get rates

Stay at this hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and a marina. Popular attractions Museum of the Kuna Nation and Porvenir Museum are located nearby.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as CA $1,194. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life’s a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You’ll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.