Southeast Missouri Vacations 2025

Top Southeast Missouri hotels deals

The Riverview

777 Main St, Cape Girardeau, MO

Free cancellation

Reserve now, pay when you stay

CA $115

CA $129 total

includes taxes & fees

1 Apr - 2 Apr

Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are located nearby.

Parking included

Free WiFi

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

Free cancellation

Reserve now, pay when you stay

CA $135

CA $153 total

includes taxes & fees

6 Apr - 7 Apr

Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are located nearby.

Pool

Hot tub

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Free cancellation

Reserve now, pay when you stay

CA $74

CA $85 total

includes taxes & fees

6 Apr - 7 Apr

Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Wilson Rozier Park and Veterans Park are located nearby.

Pool

Breakfast included

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

Free cancellation

Reserve now, pay when you stay

CA $96

CA $101 total

includes taxes & fees

1 Apr - 2 Apr

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Margaret Harwell Art Museum and Black River Coliseum are located nearby.

Pet-friendly

Parking included

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street, Cape Girardeau, MO

Free cancellation

CA $147

CA $166 total

includes taxes & fees

6 Apr - 7 Apr

Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Cape Splash Family Aquatic Center and Fort D Historic Site are located nearby.

Pool

Breakfast included

The Farmstead Hotel

778 E 3rd St, Caruthersville, MO

Free cancellation

Reserve now, pay when you stay

CA $127

CA $145 total

includes taxes & fees

1 Apr - 2 Apr

Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Century Casino Caruthersville and Caruthersville Public Library are located nearby.

Parking included

Free WiFi

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Echo Bluff State Park

You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just . Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you’re ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you’re being taken care of before, during and after your trip. And don’t panic if you notice a lower price on your booking, we’ll match it. That’s our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson’s Shut-ins State Park and Meramec Caverns while you’re here. These landmarks shouldn’t be missed.