Defiance Vacations 2025

Top Defiance hotels deals

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive, Maryland Heights, MO

Free cancellation

Reserve now, pay when you stay

CA $150

CA $195 total

includes taxes & fees

Apr 28 - Apr 29

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Hollywood Casino Amphitheatre and Ameristar Casino St. Charles are located nearby.

Parking included

Restaurant

Ameristar Casino Resort and Spa

1 Ameristar Blvd, St. Charles, MO

Free cancellation

Reserve now, pay when you stay

CA $211

CA $270 total

includes taxes & fees

Apr 20 - Apr 21

Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property condition in our reviews. Popular attractions Ameristar Casino St. Charles and Hollywood Casino Amphitheatre are located nearby.

Pool

Hot tub

The Wildwood Hotel

2801 Fountain Pl, Wildwood, MO

Free cancellation

Reserve now, pay when you stay

CA $122

CA $148 total

includes taxes & fees

Apr 15 - Apr 16

Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient parking in our reviews. Popular attractions Six Flags St. Louis and Skid Row are located nearby.

Pool

Hot tub

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive, Fenton, MO

Free cancellation

Reserve now, pay when you stay

CA $132

CA $153 total

includes taxes & fees

Apr 15 - Apr 16

Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions LIFECHURCH and Flight Range are located nearby.

Pool

Breakfast included

La Quinta Inn & Suites by Wyndham St. Louis Westport

11805 Lackland Rd, Maryland Heights, MO

Free cancellation

Reserve now, pay when you stay

CA $124

CA $143 total

includes taxes & fees

Apr 18 - Apr 19

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Westport Plaza and Hollywood Casino Amphitheatre are located nearby.

Pool

Breakfast included

Wingate by Wyndham St. Louis/Fenton Route 66

1100 S Highway Dr, Fenton, MO

Free cancellation

Reserve now, pay when you stay

CA $110

CA $127 total

includes taxes & fees

Apr 15 - Apr 16

Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions LIFECHURCH and Flight Range are located nearby.

Pool

Breakfast included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Busch Stadium

5/5(19 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a baseball game.

St. Louis Union Station

4.5/5(7 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

Gateway Arch

4.5/5(37 reviews)

Find out about the history of Gateway Arch, one of the top monuments in St. Louis. Experience the area's fascinating museums or attend a baseball game.

Defiance Vacations

Before you fly off to Defiance on a whim, take the time to learn a few facts about it.

Around 30 miles (48 kilometers) to the west of downtown St. Louis, Defiance is one of the neighborhoods that make this city so appealing.

At last count, the population of St. Louis was 320,000.

Places to visit in Defiance

The St. Louis region offers plenty of opportunities for outdoor adventures. Why not go rock climbing while you're here? If you'd like to double the fun factor, also make plans to go caving.

Where do you fly into for Defiance?

Fasten your seatbelt and get ready to touch down at Spirit of St. Louis Airport (SUS). This is the closest major terminal and it's approximately 9 miles (14 kilometers) to the east from the center of Defiance. Collect your luggage and let the fun begin!

Frequently asked questions

How much are vacation packages to Defiance?

Treat yourself to a one-of-a-kind experience in Defiance with a vacation package starting from just . Organizing your hotels, tours and flights with Travelocity is a piece of cake. What’s more, our vacation deals will leave you with extra cash for loads of fun times.

Where can I get the best vacation package deals for Defiance?

It’s difficult to beat Travelocity when it comes to piecing together your Defiance package deal. There are as many as 400 partner airlines and 1,000,000 properties around the world to choose from. Secure your trip now and get ready to cross another amazing place off your travel bucket list.

Why should I purchase my Defiance vacation package with Travelocity?

From our 24/7 customer care to our range of fantastic destinations, we’re committed to fulfilling your travel desires. All you’ll have to do is click and book — our Price Match Guarantee will make sure you score the best price.

Can I save on my Defiance car rental if I bundle it with my hotel or flight?

With a Defiance vacation package, you can bundle your hotel, car and flight bookings and save some serious money. If you’d love to discover the best of this wonderful part of the world, why not head to Busch Stadium? This popular attraction is 48 kilometers from Defiance. With your own rental car, you’ll be there before you know it.

Which airport is best for Defiance?

Lambert-St. Louis Intl. Airport (STL) is the top airport for those flying to Defiance. Once you touch down, you’ll find yourself 40 kilometers east of the downtown area.

What is there to do in Defiance?

There is a certain magic in the air as you stroll the streets of Defiance. Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center are just two famous sights that make this city so popular, so put them at the top of your must-see list.

Where should I stay when visiting Defiance?

The BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond is recommended by many travelers. Book soon to avoid missing out.