Book Best Western rooms in Serra Mesa
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Featured Serra Mesa Best Western hotels

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2485 Hotel Circle Place, San Diego, CA
Free cancellation
Reserve now, pay when you stay
The price is CA $183 per night
CA $183
CA $210 total
includes taxes & fees
May 7 - May 8
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mission Bay and San Diego Zoo are located nearby.
Pool
Hot tub

Best Western Seven Seas
411 Hotel Circle South, San Diego, CA
Free cancellation
Reserve now, pay when you stay
The price is CA $126 per night
CA $126
CA $145 total
includes taxes & fees
May 5 - May 6
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions San Diego Zoo and Balboa Park are located nearby.
Pool
Hot tub

Best Western Chula Vista/Otay Valley Hotel
4450 Main Street, Chula Vista, CA
Free cancellation
Reserve now, pay when you stay
The price is CA $158 per night
CA $158
CA $174 total
includes taxes & fees
May 20 - May 21
Book a stay at this business-friendly hotel in Chula Vista. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions North Island Credit Union Amphitheatre and Las Americas Premium Outlets are located nearby.
Pool
Breakfast included

Best Western Yacht Harbor Hotel
5005 N Harbor Dr, San Diego, CA
Free cancellation
Reserve now, pay when you stay
The price is CA $183 per night
CA $183
CA $210 total
includes taxes & fees
May 7 - May 8
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions USS Midway Museum and Port of San Diego are located nearby.
Pool
Hot tub

Best Western San Diego/Miramar Hotel
Free cancellation
Reserve now, pay when you stay
The price is CA $143 per night
CA $143
CA $164 total
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free parking, and a 24-hour front desk. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Westfield UTC and Mission Trails Regional Park are located nearby.
Pool
Breakfast included

Best Western Americana Inn
815 W San Ysidro Boulevard, San Ysidro, CA
Free cancellation
Reserve now, pay when you stay
The price is CA $145 per night
CA $145
CA $163 total
includes taxes & fees
May 20 - May 21
Stay at this hotel in San Ysidro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Las Americas Premium Outlets and North Island Credit Union Amphitheatre are located nearby.
Pool
Breakfast included

Best Western Santee Lodge
10726 Woodside Ave, Santee, CA
Free cancellation
Reserve now, pay when you stay
The price is CA $179 per night
CA $179
CA $198 total
includes taxes & fees
May 7 - May 8
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions Creation and Earth History Museum and Sportsplex USA Santee are located nearby.
Pool
Hot tub

Best Western Poway/San Diego Hotel
13845 Poway Rd, Poway, CA
Free cancellation
Reserve now, pay when you stay
The price is CA $136 per night
CA $136
CA $150 total
includes taxes & fees
May 6 - May 7
Book a stay at this business-friendly hotel in Poway. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Iron Mountain and Poway-Midland Railroad are located nearby.
Pool
Breakfast included

Best Western Downtown San Diego
840 A Street, San Diego, CA
Free cancellation
Reserve now, pay when you stay
The price is CA $201 per night
CA $201
CA $229 total
includes taxes & fees
May 1 - May 2
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
Breakfast included
Free WiFi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent Serra Mesa hotel reviews by fellow wanderers

Wyndham San Diego Bayside
5 out of 5
Posted 10 hours ago
Travelocity Verified Review
"We arrived in San Diego via cruise ship and choose the Wyndam because of it's proximity to the cruise port. A short (under 5 mins) walk got us to our destination. There is a lot to do in the area and also plenty of dining options. The hotel is very nice, the staff members that we spoke with were very nice and easy to deal with. We would be happy to stay here again if the opportunity were to arise."
A verified traveller stayed at Wyndham San Diego Bayside